Vancomycin–Teixobactin

From the Nowick Lab

Vancomycin, a cornerstone antibiotic for Gram-positive infections, faces diminishing efficacy due to the emergence of vancomycin-resistant Enterococci, VRE, and vancomycin-resistant...

Synthesis Tag

From the Hartrampf Lab

Solid-phase peptide synthesis, SPPS, and native chemical ligation, NCL, are powerful methods for obtaining peptides and proteins that are otherwise inaccessible...

Peptide Modifications

From the Phan Lab

Ribosomally synthesized and post-translationally modified peptides, RiPPs, represent an expanding class of natural products distinguished by their extensive post-translational modifications. Among the enzymatic systems...

Genome Mining

From the Agarwal Lab

Brominated intermediates have long been favored in organic synthesis for their chemical versatility, particularly in transition-metal-assisted bond-forming reactions. The Agarwal and van der Donk study represents a significant leap...

Backbone Editing

From the Schepartz Lab

The ability to precisely manipulate the peptide backbone remains one of the fundamental challenges in biomolecular engineering. While ribosomal translation and peptide synthesis methods allow for modifications...

Super-Res Microscopy

From the Guha Lab

Researchers in the Samit Guha Group at Jadavpur University, Kolkata, India, published in Bioconjugate Chemistry, report a groundbreaking approach to cancer imaging...

Metallo-Azapeptides

From the Proulx Lab

Published in the Journal of the American Chemical Society, researchers in the Proulx group at the North Carolina State University at Raleigh, present the first approach to controlled metal …

Selective Cyclization

From the Liu Lab

To address the limitations of current methods for peptide macrocyclization, which often rely on nonspecific small-molecule linkers...

Molecular Flasks

From the Woolfson Lab

To address the formidable challenge of binding and orienting multiple small molecules for directed chemical reactions, researchers in the Woolfson and Oliver groups at the University of Bristol, published in...

Yeast CICLOPPS

From the Knudsen Lab

Researchers in the Knudsen Group at the University of Aarhus, Denmark, published in Biochemistry, report the construction of a Saccharomyces cerevisiae-specific SICLOPPS library of 80 million members...

Graspetides

From the Ding Lab

Published in ACS Chemical Biology, researchers in the Ding Group at the University of Florida, reconstructed prunipeptin biosynthesis from Streptomyces coelicolor...

Mirror-Image mRNA

From the Payne Lab

Chemokines are small proteins involved in recruiting leukocytes to sites of inflammation via interactions with specific cell surface receptors. CCL22 is a chemokine known to play a critical role in...

Biomolecular Condensates

From the Baiz Lab

Biomolecular condensates provide a mechanism for compartmentalization of biomolecules in eukaryotic cells. These liquid-like condensates are formed via liquid–liquid phase separation

Genetical Encoding

From the Schultz Lab

Nicotinamide-containing cofactors play an essential role in many enzymes that catalyze two-electron redox reactions. However, it is difficult to engineer nicotinamide binding sites into proteins due to the extended nature...

Anorexia and Weight Loss

From the Mapp Lab

The melanocortin-3 receptor, MC3R, is a G-protein coupled receptor that regulates appetite and is a potential therapeutic target for anorexia and weight loss treatments...

Mammalian Esterase Activity

From the Raines Lab

As a traceless, bioreversible modification, the esterification of carboxyl groups in peptides and proteins has the potential to increase their clinical utility. An impediment is the lack of strategies to …

Intracellular Antibodies

From the Futaki Lab

Published in Bioconjugate Chemistry, researchers from Shiroh Futaki Group at the Kyoto University, prepared conjugates of the biocompatible polysaccharide pullulan with a cell membrane permeabilizing peptide...

Cyclodepsipeptides

From the Del Valle Lab

Members of the Del Valle Group at the University of Notre Dame, in collaboration with the Ebright Group at Rutgers, report in Organic letters, the synthesis of the antimicrobial …

Macrocyclic Peptide Ligands

From the Suga Lab

Prenylation of peptides is widely observed in the secondary metabolites of diverse organisms, granting peptides unique chemical properties distinct from proteinogenic amino acids. Discovery of...

Dominant Rotor Method

From the Yudin Lab

Helical secondary structures, namely α- and 3¹⁰-helices, comprise >60% of all secondary structures observed at protein–protein interactions, PPIs, and are responsible for the mediation of many biological...